Metabolic Pathways Associated With Psychoneurological Symptoms in Children With Cancer Receiving Chemotherapy
Description
ContextChildren with cancer undergoing chemotherapy experience a cluster of psychoneurological symptoms (PNS), including pain, fatigue, anxiety, and depressive symptoms. Metabolomics is promising to differentiate metabolic pathways associated with the PNS cluster.ObjectivesIdentify metabolic pathways associated with the PNS cluster in children with cancer before and after chemotherapy.MethodsPain, fatigue, anxiety, and depressive symptoms were assessed using the Pediatric PROMIS scales. T-scores were computed and divided dichotomously by a cutoff point of 50; the PNS cluster was a sum of the four symptoms ranging from 0 (all T-scores <50) to 4 (all T-scores ≥50). Serum metabolites were processed using liquid chromatography mass-spectrometry untargeted metabolomics approach. Linear regression models examined metabolites associated with the PNS cluster. Metabolic pathway enrichment analysis was performed.ResultsParticipant demographics (n = 40) were 55% female, 60% white, 62.5% aged 13–19 years, and 62.5% diagnoses of Hodgkin’s lymphoma and B-cell acute lymphocytic leukemia. Among 9276 unique metabolic features, 454 were associated with pain, 281 with fatigue, 596 with anxiety, 551 with depressive symptoms, and 300 with the PNS cluster across one chemotherapy cycle. Fatty acids pathways were associated with pain: de novo fatty acid biosynthesis (p < .001), fatty acid metabolism (p = .001), fatty acid activation (p = .004), and omega-3 fatty acid metabolism (p = .009). Tryptophan amino acid pathway was associated with fatigue (p < .001), anxiety (p = .015), and the PNS cluster (p = .037). Carnitine shuttle was associated with the PNS cluster (p = .015).ConclusionFatty acids and amino acids pathways were associated with PNS in children undergoing chemotherapy. These findings require further investigation in a larger sample.
Publication Date
1-1-2022
Publisher
figshare SAGE Publications
DOI
10.25384/sage.c.5891794.v1
Document Type
Data Set
Recommended Citation
Eldridge, Ronald C.; Bai, Jinbing; Withycombe, Janice (2022), "Metabolic Pathways Associated With Psychoneurological Symptoms in Children With Cancer Receiving Chemotherapy", figshare SAGE Publications, doi: 10.25384/sage.c.5891794.v1
https://doi.org/10.25384/sage.c.5891794.v1
Identifier
10.25384/sage.c.5891794.v1
Embargo Date
1-1-2022