Associations of RPEL1 and miR-1307 gene polymorphisms with disease susceptibility, glucocorticoid efficacy, anxiety, depression, and health-related quality of life in Chinese systemic lupus erythematosus patients

Creators

Wan-Qin Hu, Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University
Yang-Fan Chen, Department of Rheumatology and Immunology, The First Affiliated Hospital of Anhui Medical University
Yu-Hua Wang, The Key Laboratory of Anhui Medical Autoimmune Diseases (Anhui Medical University)
Hai-Feng Pan, The Key Laboratory of Anhui Medical Autoimmune Diseases (Anhui Medical University)
Zhou-Zhou Xu, Department of Rheumatology and Immunology, The Second Affiliated Hospital of Anhui Medical University
Fa-Ming Pan, The Key Laboratory of Anhui Medical Autoimmune Diseases (Anhui Medical University)
Mu Li, Department of Rheumatology and Immunology, The First Affiliated Hospital of Anhui Medical University
Yan-Feng Zou, Key Laboratory of Dermatology, (Anhui Medical University), Ministry of Education
Zhen Li, Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University
Guang-Hui Yu, Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University
Jing Cai, Department of Rheumatology and Immunology, The First Affiliated Hospital of Anhui Medical University
Qi-Qun Zong, The Key Laboratory of Anhui Medical Autoimmune Diseases (Anhui Medical University)
Ying Teng, Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University
Zi-Ye Yan, Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University
Ting-Yu Zhang, Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University
Lin-Lin Wang, The Key Laboratory of Anhui Medical Autoimmune Diseases (Anhui Medical University)
Chun-Xia Zhai, The Key Laboratory of Anhui Medical Autoimmune Diseases (Anhui Medical University)
Hong Su, The Key Laboratory of Anhui Medical Autoimmune Diseases (Anhui Medical University)

Description

ObjectiveOur present study intended to examine the associations of RPEL1 and miR-1307 gene polymorphisms (rs4917385 and rs7911488) with susceptibility, glucocorticoids (GCs) efficacy, anxiety, depression, and health-related quality of life (HRQoL) in Chinese systemic lupus erythematosus (SLE) patients.MethodsInitially, 1000 participants (500 SLE cases and 500 controls) were recruited for the case–control study. Then, 429 cases who received GCs were followed through 12 weeks to explore GCs efficacy, depression, anxiety, and HRQoL. We selected the iMLDR technique for genotyping: RPEL1: rs4917385 (G/T) and miR-1307: rs7911488 (A/G).ResultsThe minor G allele of rs7911488 reduced the risk of SLE (p = .024). Four haplotypes consisting of rs4917385 and rs7911488 were associated with SLE susceptibility (p < .025). Both rs4917385 and rs7911488 were associated with anxiety symptoms and physical function (PF) in SLE patients (p < .025). The rs4917385 was associated with depression and its improvement. No statistical significance was found between RPEL1 and miR-1307 gene polymorphisms with GCs efficacy. Meanwhile, additive interaction analysis showed a significant association between RPEL1 and miR-1307 gene polymorphisms with tea consumption in anxiety.ConclusionRPEL1 and miR-1307 gene polymorphisms (rs4917385 and rs7911488) might be related to SLE susceptibility in Chinese population. Additionally, the two polymorphisms were possibly associated with depression, anxiety, and HRQoL in Chinese SLE population.

Publication Date

1-1-2022

Publisher

figshare SAGE Publications

DOI

10.25384/sage.c.6232855.v1

Document Type

Data Set

Identifier

10.25384/sage.c.6232855.v1

Embargo Date

1-1-2022

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