Document Type
Patent
Publication Date
9-24-2002
Patent Number
patent number 6455546
Abstract
The present invention generally relates to various methods for promoting ovulation, parturition and lactation in female mammals. These benefits are obtained by administering to the mammals a composition containing a D.sub.2 receptor antagonist that does not substantially cross the blood brain barrier. In one embodiment, the D.sub.2 receptor antagonist is domperidone. The domperidone can be administered to the mammal either orally or subcutaneously and can be used to treat, for instance, anestrous mammals, mammals that have problems bearing offspring and mammals suffering from agalactia. Unexpectedly, it has also been discovered that the D.sub.2 receptor antagonist may also stimulate feed intake, causing the mammal to eat more and gain weight faster.
Application Number
09/783114
Assignees
Clemson University (Clemson, SC)
Filing Date
2001-02-14
Primary/U.S. Class
514/322
Other/U.S. Class
424/442, 514/276, 514/277, 514/437, 514/450