Document Type

Patent

Publication Date

11-23-2010

Patent Number

patent number 7838000

Abstract

Disclosed are treatment agents and methods of treatment utilizing the agents directed toward diseases in which the disease causing pathogen includes .alpha.6.beta.1 integrin receptors and/or .alpha.6.beta.4 integrin receptors on the surface of the pathogen. In one embodiment, the disease can be breast cancer. The therapeutic agents disclosed include a polypeptide comprising at least a portion of the G domain of the laminin-5 .alpha.3 chain that has been shown to bind .alpha.6.beta.1 integrin receptors and .alpha.6.beta.4 integrin receptors. In one embodiment, the therapeutic agents can be fused or chimeric materials in which the laminin-5 .alpha.3 chain polypeptide has been chemically bound to another material that can be useful in the destruction or neutralization of the pathogen.

Application Number

11/440746

Assignees

Clemson University Research Foundation (Clemson, SC, US)

Filing Date

2006-05-25

Primary/U.S. Class

424/184.1

Other/U.S. Class

514/19.4

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