Document Type
Patent
Publication Date
3-27-2012
Patent Number
patent number 8142805
Abstract
Disclosed are implantable tissues including one or more enzyme inhibitors bound in the tissues, bioprostheses including the tissue, and methods for incorporating enzyme inhibitors in implantable tissues. Disclosed tissue can exhibit increased resistance to degradation, and specifically, degradation due to enzyme activity following implantation. Moreover, the disclosed methods can lead to increased levels of beneficial components bound in implantable tissues following a fixation/stabilization protocol. Increased levels of beneficial agents in an implantable tissue can further improve the implantable tissues and bioprostheses incorporating the tissues through improved mechanical characteristics and longer lifespan.
Application Number
11/934844
Assignees
Clemson University Research Foundation (Clemson, SC, US)
Filing Date
2007-11-05
Primary/U.S. Class
424/422
Other/U.S. Class
424/94.1, 424/400, 435/183, 435/325