Document Type

Patent

Publication Date

3-27-2012

Patent Number

patent number 8142805

Abstract

Disclosed are implantable tissues including one or more enzyme inhibitors bound in the tissues, bioprostheses including the tissue, and methods for incorporating enzyme inhibitors in implantable tissues. Disclosed tissue can exhibit increased resistance to degradation, and specifically, degradation due to enzyme activity following implantation. Moreover, the disclosed methods can lead to increased levels of beneficial components bound in implantable tissues following a fixation/stabilization protocol. Increased levels of beneficial agents in an implantable tissue can further improve the implantable tissues and bioprostheses incorporating the tissues through improved mechanical characteristics and longer lifespan.

Application Number

11/934844

Assignees

Clemson University Research Foundation (Clemson, SC, US)

Filing Date

2007-11-05

Primary/U.S. Class

424/422

Other/U.S. Class

424/94.1, 424/400, 435/183, 435/325

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