Document Type

Patent

Publication Date

7-10-2012

Patent Number

patent number 8217161

Abstract

The present invention relates to siRNAs that are targeted to RNAs encoding two or more enzymes of a subfamily of cytochrome P450 (CYP) enzymes, along with vectors, cells, and kits comprising the siRNAs. The invention further relates to methods of decreasing expression of two or more CYP subfamily genes in a non-human animal, animals in which expression of two or more CYP subfamily genes has been decreased, and methods of using such animals to study the function of cytochrome P450 enzymes.

Application Number

12/427791

Assignees

Clemson University Research Foundation (Clemson, SC, US)

Filing Date

2009-04-22

Primary/U.S. Class

536/24.5

Other/U.S. Class

435/6.1, 435/325, 536/23.1

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