Document Type

Patent

Publication Date

9-10-2013

Patent Number

patent number 8529951

Abstract

Disclosed are elastogenic cues that can be utilized to encourage growth and development of elastin-containing cellular constructs. The elastogenic cues include hyaluronan fragments and oligomers, optionally in conjunction with growth factors and/or a source of copper ions. The elastogenic cues can up-regulate elastin matrix synthesis and by vascular smooth muscle cells. In addition to encouraging synthesis of elastin in a cellular matrix and organization into elastic fibers, the elastogenic cues can also stabilize the formed ECM matrix through suppression of elastin-laminin receptor (ELR). In addition, the elastogenic cues can inhibit cell hyper-proliferation (e.g., hyperplasia) common in inflammatory vascular disease.

Application Number

12/034237

Filing Date

2008-02-20

Primary/U.S. Class

424/488

Other/U.S. Class

424/461, 424/493, 514/7.6, 514/54, 514/499

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