Understanding the Role of NADH in Cellular Fe2+ Generation of Hydroxyl Radical and the Effects of Polyphenol Antioxidants

Authors

Craig Goodman, Clemson University
Julia L. Brumaghim, Clemson University

Document Type

Poster

Publication Date

3-2016

Abstract

Structurally similar polyphenols have opposite effects on rates of Fe3+ reduction by NADH. In future work, we anticipate exploring several avenues:

What is the role of autoxidation? UV-vis kinetic experiments in an air-free atmosphere should reveal if MEGA is increasing the pool of reducible Fe3+.

What occurs in the presence of H2O2 and/or increased levels of NADH? Mimicking the environment of a stressed cell should yield interesting information about antioxidant activity if the rates change significantly.

Recommended Citation

Goodman, Craig and Brumaghim, Julia L., "Understanding the Role of NADH in Cellular Fe2+ Generation of Hydroxyl Radical and the Effects of Polyphenol Antioxidants" (2016). Chemistry Annual Research Symposium. 8.
https://open.clemson.edu/cars/8