Document Type

Patent

Publication Date

7-13-2010

Patent Number

patent number 7754241

Abstract

A degradable hydrogel and a method of making a degradable hydrogel is disclosed herein. The method comprises obtaining a hydrophilic polymer having at least two hydroxyl groups, reacting the hydrophilic polymer with a di-functional monomer comprised of an acid halide group and an alkyl halide group to form an intermediate having an ester bond and a terminal alkyl halide group, reacting the terminal alkyl halide group of the intermediate with a metallic salt of a vinyl acid monomer to form a macromonomer comprised of an ester, an alkyl group spacer, and a terminal vinyl group, and polymerizing the macromonomer to form a degradable hydrogel. A method is also disclosed for varying the degradation rate of the hydrogel as a function of the chemical composition of the alkyl group spacer in the terminal linkage of the macromonomer.

Application Number

11/271405

Assignees

Clemson University Research Foundation

Filing Date

2005-11-10

Primary/U.S. Class

424/486

Other/U.S. Class

424/400, 424/423, 424/487, 435/180, 435/182, 530/815, 530/817

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